DSIP
DSIP research compound, also known as Delta Sleep-Inducing Peptide. Supplied as a lyophilized peptide reference material for laboratory research applications.
This product is purity-tested for compound identity and is intended for in vitro experimentation, analytical reference, or scientific characterization studies.
For laboratory research use only. Not for human or veterinary use.
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Product Details
Characteristics
| Molecular Formula | C35H48N10O15 |
| CAS | 62568-57-4 |
| Molar Mass | 1397.8 g/mol |
| Chemical Formula | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Synonyms | Delta Sleep-Inducing Peptide, DSIP, Deltaran, Emideltide |
| Solubility | Water-soluble |
| Organoleptic Profile | White to off-white powder |
| Composition | Lyophilized powder – requires reconstitution |
How does DSIP work?
DSIP peptide exerts its effects through interactions with specific receptors in the brain and peripheral tissues. Although the precise mechanisms of action of Delta Sleep-Inducing Peptide (DSIP) are not fully understood, research suggests that DSIP peptide modulates multiple neurotransmitter systems, including glutamate, GABA, and serotonin. By influencing these neurotransmitters, peptide DSIP can promote slow-wave sleep, regulate sleep-wake cycles, and modulate stress responses. Additionally, peptide DSIP has been shown to interact with the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in stress adaptation and immune function.
Benefits
- Promotes slow-wave sleep: DSIP peptide has been demonstrated to increase the duration and quality of slow-wave sleep, which is essential for physical and mental restoration.
- Regulates circadian rhythms: Studies suggest that Delta Sleep-Inducing Peptide (DSIP) plays a role in synchronizing circadian rhythms, potentially benefiting individuals with sleep disorders or jet lag.
- Stress management: DSIP has been shown to modulate the stress response by influencing the HPA axis, which may help in reducing the negative effects of chronic stress.
- Neuroprotective properties: Some research indicates that DSIP peptide benefits may possess neuroprotective properties, potentially offering therapeutic benefits in neurodegenerative disorders.
- Immunomodulatory effects: DSIP has been reported to modulate immune function, which may have implications for various immune-related disorders.
Side Effects
DSIP peptide is generally well-tolerated, and side effects are rare when used at recommended doses. However, some potential side effects may include:
- Headache
- Dizziness
- Gastrointestinal discomfort
- Allergic reactions (rare)
Summary
Delta Sleep-Inducing Peptide (DSIP) is a promising neuromodulator with growing research interest in sleep regulation, stress management, and neuroprotection. Through its interaction with key neurotransmitter systems and the hypothalamic-pituitary-adrenal (HPA) axis, DSIP peptide supports slow-wave sleep activity, helps regulate circadian rhythms, and modulates physiological stress responses. While current studies highlight several DSIP peptide benefits, further research is required to fully clarify its mechanisms of action and long-term safety profile. As a research peptide, peptide DSIP continues to offer valuable opportunities for advancing scientific understanding of sleep physiology, stress adaptation, and neurological function.
References
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006.
- Yehuda S, Carasso RL. DSIP–a tool for investigating the sleep onset mechanism: a review. Int J Neurosci. 1988.
- Schneider-Helmert D. DSIP in insomnia. Eur Neurol. 1984.
- Schneider-Helmert D. DSIP in sleep disturbances. Eur Neurol. 1986.
- Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984.
- Graf MV, Kastin AJ, Fischman AJ. DSIP occurs in free form in mammalian plasma, human CSF and urine. Pharmacol Biochem Behav. 1984.
- Graf MV, Kastin AJ, Coy DH, Zadina JE. DSIP reduces amphetamine-induced hyperthermia in mice. Physiol Behav. 1984.
- Pollard BJ, Pomfrett CJ. Delta sleep-inducing peptide. Eur J Anaesthesiol. 2001
- Banks WA, Kastin AJ, Selznick JK. Modulation of immunoactive levels of DSIP and blood-brain permeability by lighting and diurnal rhythm. J Neurosci Res. 1985.
- Tsunashima K, Masui A, Kato N. The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats. Brain Res. 1990.
Certificate of Analysis (COA)

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