5-Amino-1MQ Research Kit

5-Amino-1MQ is studied in laboratory and preclinical research as a tool to investigate NNMT activity and its influence on metabolic and cellular pathways. Typical research applications include:

• Enzyme inhibition studies: Measuring NNMT activity and the effects of 5-Amino-1MQ on methylation pathways.
• Metabolic pathway modeling: Evaluating the compound’s impact on NAD+ metabolism, energy regulation, and related molecular pathways.
• Delivery evaluations: Using the spray kit to compare absorption efficiency, solution stability, and alternative administration routes.
• Cellular assays: Investigating effects on cellular metabolism, mitochondrial function, and experimental metabolic models.

• Metabolic research: Examining NNMT activity and its modulation in cell and tissue models.
• Cellular energy regulation: Studying effects on NAD+ turnover, mitochondrial respiration, and metabolic signaling.
• Obesity and adipose tissue models: Experimental studies modeling NNMT’s role in fat metabolism and energy homeostasis.
• Liver and kidney metabolism: Investigating molecular pathways in hepatic and renal cells under controlled conditions.
• Preclinical pharmacology: Laboratory research exploring compound stability, enzyme interactions, and downstream signaling.

The 5-Amino-1MQ Research Spray Kit contains a selective NNMT inhibitor supplied as a lyophilized powder with a precision spray system for controlled laboratory use. The kit allows for evaluation of multiple administration routes, absorption efficiency, and solution stability while supporting research into metabolic regulation, cellular energy pathways, and enzyme activity. This product is intended exclusively for research use.

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5. Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375.